A series of substituted 5-phenylpropenylidene-2,4-thiazolidinediones was synthesized by the condensation of different substituted benzalacetones and substituted cinnamaldehydes with 2, 4-thiazolidinedione by Knoevenagel reaction. The antioxidant activity of synthesized compounds was determined by using nitric oxide scavenging method. The synthesized compounds were found to have excellent anti-oxidant activity when compared to standard, vitamin-C. The antihyperglycemic activity of the synthesized compounds was determined using Oral Glucose Tolerance Test (OGTT), carried out on streptozotocin induced diabetic rat model. The test compounds showed significant antihyperglycemic activity when compared with standard drug, rosiglitazone.
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